In-Silico Design of 3D Biomimetic Nanofibrous Scaffolds for Tissue Engineering: Development of Parametric Geometries, Meshing and Automated Calculation

Authors

  • Gustavo E. Carr Universidad Nacional de Mar del Plata, Facultad de Ingeniería, Departamento de Mecánica, GIAC & Grupo Polímeros Biomédicos, INTEMA & CONICET. Mar del Plata, Argentina.
  • Nahuel M. Jáuregui Universidad Nacional de Mar del Plata, Facultad de Ingeniería, Departamento de Mecánica, GIAC & CONICET. Mar del Plata, Argentina.
  • Nicolás A. Antonelli Universidad Nacional de Mar del Plata, Facultad de Ingeniería, Departamento de Mecánica, GIAC & Grupo Polímeros Biomédicos, INTEMA & Universidad Tecnológica Nacional, Facultad Regional Mar del Plata, HidroSim. Mar del Plata, Argentina.
  • Florencia Montini Ballarín Instituto de Investigaciones en Ciencia y Tecnología de Materiales (UNMdP-CONICET), Grupo Polímeros Biomédicos & CONICET. Mar del Plata, Argentina.
  • Santiago A. Urquiza Universidad Nacional de Mar del Plata, Facultad de Ingeniería, Departamento de Mecánica, GIAC & Universidad Tecnológica Nacional, Facultad Regional Mar del Plata, HidroSim. Mar del Plata, Argentina.

DOI:

https://doi.org/10.70567/mc.v41i17.89

Keywords:

Automated parametric modeling, Biomimetic nanofibrous scaffolds, Finite Elements Method, In-silico testing, Hyperelasticity

Abstract

Multiscale computational modeling allows the design of synthetic fibrous matrices to reproduce the mechanical behavior of biological tissues. The aim of this work is to develop a method to obtain CAD designs of artificial tissues (scaffolds) for automated in-silico uniaxial testing. A software was developed to automatically generate a parametric library of geometries to replace complex tissue microstructures. In-silico tensile tests were performed, the results obtained were presented and a discussion was made regarding the geometric variations studied.

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Published

2024-11-08

Issue

Vol. 41 No. 17 (2024): Computational Modeling in Bioengineering, Biomechanics, and Biomedical Systems

Section

Conference Papers in MECOM 2024

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Copyright (c) 2024 Argentine Association for Computational Mechanics

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